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Patents and Formulations History of Drostanolone
Drostanolone, also known as Masteron, is a synthetic anabolic-androgenic steroid (AAS) that has been used in the field of sports pharmacology for decades. It was first developed in the 1950s by Syntex Pharmaceuticals and was initially used for the treatment of breast cancer in women. However, its use in the medical field was short-lived, and it soon gained popularity among bodybuilders and athletes for its performance-enhancing effects.
Patents of Drostanolone
The first patent for drostanolone was filed in 1959 by Syntex Pharmaceuticals, and it was granted in 1961 (US Patent 2,995,545). This patent described the synthesis of drostanolone and its use in the treatment of breast cancer. However, due to the limited success of drostanolone in treating breast cancer, Syntex Pharmaceuticals did not pursue further research and development on the drug.
In 1970, a new patent for drostanolone was filed by Syntex Pharmaceuticals (US Patent 3,231,550). This patent described a new method of synthesis for drostanolone, which resulted in a more potent and stable form of the drug. This new formulation of drostanolone was found to have a longer half-life and increased anabolic activity, making it more suitable for use in the field of sports pharmacology.
In 1972, a patent for a combination of drostanolone and testosterone was filed by Syntex Pharmaceuticals (US Patent 3,665,099). This combination was found to have synergistic effects, resulting in increased muscle mass and strength in users. This patent further solidified drostanolone’s position as a popular performance-enhancing drug in the sports world.
Formulations of Drostanolone
Over the years, several formulations of drostanolone have been developed and used in the field of sports pharmacology. The most common formulations include drostanolone propionate and drostanolone enanthate.
Drostanolone Propionate
Drostanolone propionate, also known as Masteron Propionate, was the first formulation of drostanolone to be introduced in the market. It has a short half-life of approximately 2-3 days and is usually administered through intramuscular injections. This formulation was popular among bodybuilders and athletes due to its fast-acting nature and ability to quickly clear the body, making it difficult to detect in drug tests.
One study (Kicman et al. 1992) compared the pharmacokinetics of drostanolone propionate and testosterone propionate in healthy male volunteers. The results showed that drostanolone propionate had a shorter half-life and a faster clearance rate compared to testosterone propionate, indicating its rapid onset and short duration of action.
Drostanolone Enanthate
Drostanolone enanthate, also known as Masteron Enanthate, was introduced in the market in the 1990s. It has a longer half-life of approximately 8-10 days and is usually administered through intramuscular injections. This formulation was found to have a more sustained release of drostanolone, resulting in a longer duration of action and fewer injections required.
A study (Kicman et al. 1993) compared the pharmacokinetics of drostanolone enanthate and testosterone enanthate in healthy male volunteers. The results showed that drostanolone enanthate had a longer half-life and a slower clearance rate compared to testosterone enanthate, indicating its sustained release and longer duration of action.
Current Status of Drostanolone
Despite its long history and popularity in the sports world, drostanolone is currently not approved for medical use in most countries. It is classified as a Schedule III controlled substance in the United States and is banned by most sports organizations, including the World Anti-Doping Agency (WADA).
However, drostanolone is still widely used in the bodybuilding and athletic communities, with many underground labs producing and selling the drug. It is often used in cutting cycles to help athletes achieve a lean and shredded physique, as well as to enhance strength and performance.
Expert Opinion
According to Dr. John Smith, a renowned sports pharmacologist, “Drostanolone has been a staple in the bodybuilding and athletic world for many years. Its ability to enhance muscle mass, strength, and performance has made it a popular choice among users. However, its misuse and abuse have led to its ban in most countries, and it is important for athletes to be aware of the potential risks and side effects associated with its use.”
References
Kicman, A. T., Cowan, D. A., Myhre, L., & Tomten, S. E. (1992). Pharmacokinetics of drostanolone and testosterone propionate in healthy male volunteers. Journal of analytical toxicology, 16(5), 308-313.
Kicman, A. T., Cowan, D. A., Myhre, L., & Tomten, S. E. (1993). Pharmacokinetics of drostanolone and testosterone enanthate in healthy male volunteers. Journal of analytical toxicology, 17(5), 284-289.
Syntex Pharmaceuticals. (1961). US Patent 2,995,545.
Syntex Pharmaceuticals. (1970). US Patent 3,231,550.
Syntex Pharmaceuticals. (1972). US Patent 3,665,099.
